Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 4/20 | 0.34 |
| ▸ | RCOR1 | Q9UKL0 | 4/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | WHR1 | P49842 | 1/20 | 0.34 |
| ▸ | SPIN4 | Q56A73 | 1/20 | 0.33 |
| ▸ | SPIN3 | Q5JUX0 | 1/20 | 0.33 |
| ▸ | SPIN2B | Q9BPZ2 | 1/20 | 0.33 |
| ▸ | SPIN1 | Q9Y657 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776163 | 0.88 | POLB (0.41) | RAD52SCN9A | |
| SCHEMBL2776640 | 0.88 | KDM1A (0.42) | RAD52SCN9AKDM1ARCOR1EHMT2 | |
| SCHEMBL2776095 | 0.80 | CA12 (0.34) | — | |
| SCHEMBL6833397 | 0.80 | CRHBP (0.43) | RAD52SCN9AKDM1ARCOR1EHMT2 | |
| SCHEMBL2774178 | 0.79 | KCNH2 (0.40) | RAD52KDM1ARCOR1EHMT2 | |
| SCHEMBL14428384 | 0.78 | BRD4 (0.40) | RAD52BRAFKDM1ARCOR1EHMT2 | |
| SCHEMBL2776366 | 0.78 | SCN9A (0.42) | SCN9AKDM1ARCOR1EHMT2 | |
| SCHEMBL6679102 | 0.76 | FLT3 (0.39) | KDM1ARCOR1EHMT2WHR1 | |
| SCHEMBL6677683 | 0.76 | KCNH2 (0.36) | KDM1ARCOR1EHMT2WHR1SYK | |
| SCHEMBL6673922 | 0.75 | DNM2 (0.37) | RAD52KDM1ARCOR1EHMT2WHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816521-B2 | 1,2,4-benzotriazine-1,4-dioxides | AUCKLAND UNISERVICES LIMITED (NZ) | 2010-10-19 | — | — | US | disclosed |
| US-7816521-B2 | 1,2,4-benzotriazine-1,4-dioxides | AUCKLAND UNISERVICES LIMITED (NZ) | 2010-10-19 | — | — | US | disclosed |
| US-20070197534-A1 | Novel 1,2,4-benzotriazine-1,4-dioxides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-08-23 | — | — | US | disclosed |
| US-20070197534-A1 | Novel 1,2,4-benzotriazine-1,4-dioxides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197534-A1 | Novel 1,2,4-benzotriazine-1,4-dioxides | HIF1AN, HIF1A, HYOU1 | RAD52 1139/4885BRAF 4492/4885SCN9A 3016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.