Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 10/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27765780 | 0.93 | NR1H2 (0.35) | NOTUMNR1H2NR1H3HSD11B1 | |
| SCHEMBL27744699 | 0.87 | NOTUM (0.44) | NOTUMNR1H2NR1H3HSD11B1 | |
| SCHEMBL27765621 | 0.86 | RORC (0.36) | NOTUMNR1H2NR1H3 | |
| SCHEMBL27765640 | 0.85 | NOTUM (0.42) | NOTUMNR1H2NR1H3HSD11B1 | |
| SCHEMBL1471063 | 0.85 | NOTUM (0.47) | NOTUMNR1H2NR1H3HSD11B1 | |
| SCHEMBL28780732 | 0.82 | SLC6A9 (0.35) | HSD11B1 | |
| SCHEMBL27744574 | 0.82 | F13A1 (0.39) | NR1H2NR1H3DPP4 | |
| SCHEMBL27765691 | 0.79 | NOTUM (0.36) | NOTUMNR1H2NR1H3 | |
| SCHEMBL20309080 | 0.78 | NOTUM (0.49) | NOTUMNR1H2NR1H3DPP4 | |
| SCHEMBL1471118 | 0.78 | HSD11B1 (0.41) | NOTUMNR1H2NR1H3HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101421258-B | Sulfonyl-substituted bicyclic compounds as PPAR modulators | KALYPSYS INC | 2013-08-21 | — | — | CN | disclosed |
| CN-101421258-A | Sulfonyl-substituted bicyclic compounds as PPAR modulators | KALYSPSYS INC (US) | 2009-04-29 | — | — | CN | disclosed |