Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 13/20 | 0.83 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.83 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.69 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.63 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.63 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12394493 | 0.91 | FFAR1 (1.00) | FFAR1KEAP1FFAR4HDAC3MAPK1 | |
| Phenyl Propionic Acid SCHEMBL27523271 | 0.91 | KEAP1 (1.00) | FFAR1KEAP1FFAR4HDAC3MAPK1 | |
| Phenyl Propionic Acid SCHEMBL235064 | 0.91 | KEAP1 (1.00) | FFAR1KEAP1FFAR4HDAC3MAPK1 | |
| Phenyl Propionic Acid SCHEMBL3419 | 0.91 | KEAP1 (1.00) | FFAR1KEAP1FFAR4HDAC3MAPK1 | |
| Phenyl Propionic Acid SCHEMBL29619843 | 0.91 | KEAP1 (1.00) | FFAR1KEAP1FFAR4HDAC3MAPK1 | |
| Phenyl Propionic Acid SCHEMBL13618844 | 0.91 | KEAP1 (1.00) | FFAR1KEAP1FFAR4HDAC3MAPK1 | |
| Phenyl Propionic Acid SCHEMBL14715905 | 0.89 | KEAP1 (0.95) | FFAR1KEAP1FFAR4HDAC3MAPK1 | |
| Phenyl Propionic Acid SCHEMBL3478262 | 0.89 | KEAP1 (0.95) | FFAR1KEAP1FFAR4HDAC3MAPK1 | |
| Phenyl Propionic Acid SCHEMBL9122761 | 0.89 | KEAP1 (0.95) | FFAR1KEAP1FFAR4HDAC3MAPK1 | |
| Phenyl Propionic Acid SCHEMBL8901632 | 0.89 | KEAP1 (0.95) | FFAR1KEAP1FFAR4HDAC3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3615515-A2 | PROPIONIC ACID DERIVATIVES AND METHODS OF USE THEREOF | Aviara Pharmaceuticals, Inc. (US) | 2020-03-04 | — | — | EP | disclosed |
| WO-2018209363-A2 | PROPIONIC ACID DERIVATIVES AND METHODS OF USE THEREOF | AVIARA PHARMACEUTICALS, INC (US) | 2018-11-15 | — | — | WO | disclosed |
| US-20140045800-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-02-13 | — | — | US | disclosed |
| US-8372823-B2 | Tetracyclic inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-02-12 | — | — | US | disclosed |
| EP-2152082-B1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | SCRIPPS RESEARCH INST (US) | 2012-08-29 | — | — | EP | disclosed |
| US-20100249078-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPS RESEARCH INSTITUTE (US) | 2010-09-30 | — | — | US | disclosed |
| EP-2152082-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | The Scripps Research Institute (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008147553-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249078-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, APEH | FFAR1 16/4885KEAP1 1371/4885TBXAS1 265/4885 |
| US-20140045800-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, APEH | FFAR1 16/4885KEAP1 1371/4885TBXAS1 265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.