Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.61 |
| ▸ | RAB9A | P51151 | 7/20 | 0.61 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.60 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.60 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.60 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3519327 | 0.88 | KMT2A (0.62) | NPC1RAB9ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3517487 | 0.85 | NPC1 (0.48) | NPC1RAB9ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL28893760 | 0.81 | NPC1 (0.65) | NPC1RAB9APTGS2 | |
| SCHEMBL3636008 | 0.81 | NPC1 (0.65) | NPC1RAB9APTGS2 | |
| SCHEMBL4324471 | 0.79 | NPC1 (0.51) | NPC1RAB9AKMT2APTGS2POLB | |
| SCHEMBL30345390 | 0.78 | CHRNB2 (0.65) | CHRNB2CHRNB4CHRNA3CHRNA4HTT | |
| SCHEMBL1826396 | 0.78 | CHRNB2 (0.65) | CHRNB2CHRNB4CHRNA3CHRNA4HTT | |
| SCHEMBL7954413 | 0.77 | NPC1 (0.59) | NPC1RAB9AKMT2APTGS2POLB | |
| SCHEMBL28438384 | 0.77 | GAA (0.59) | CHRNB2CHRNB4CHRNA3CHRNA4HTT | |
| SCHEMBL5120704 | 0.76 | RAB9A (1.00) | NPC1RAB9AKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102351732-B | Nuclear receptor binding agents | GTX INC. (US) | 2014-10-29 | — | — | CN | disclosed |
| CN-103957706-A | Estrogen receptor ligands and methods of use thereof | GTX INC | 2014-07-30 | — | — | CN | disclosed |
| CN-102858154-A | Estrogen receptor ligands and methods of use thereof | GTX INC | 2013-01-02 | — | — | CN | disclosed |
| CN-102413692-A | Estrogen receptor ligands and methods of use thereof | GTX INC | 2012-04-11 | — | — | CN | disclosed |
| CN-101336227-A | Nuclear receptor binding agents | GTX INC (US) | 2008-12-31 | — | — | CN | disclosed |