Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.65 |
| ▸ | RAB9A | P51151 | 8/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28893760 | 0.83 | NPC1 (0.65) | NPC1RAB9AHDAC3ALDH1A1L3MBTL1 | |
| SCHEMBL27745804 | 0.81 | NPC1 (0.61) | NPC1RAB9APTGS2 | |
| SCHEMBL6797269 | 0.80 | NPC1 (0.56) | NPC1RAB9AHDAC3NCOR2PTGS2 | |
| SCHEMBL7945840 | 0.80 | RAB9A (0.70) | NPC1RAB9AALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL7954413 | 0.80 | NPC1 (0.59) | NPC1RAB9AHDAC3NCOR2TDP1 | |
| SCHEMBL1558090 | 0.79 | ALDH1A1 (0.59) | NPC1RAB9AALDH1A1HPGDHSD17B10 | |
| SCHEMBL5120704 | 0.79 | RAB9A (1.00) | NPC1RAB9AHDAC3ALDH1A1SMN1; SMN2 | |
| SCHEMBL7610748 | 0.78 | NPC1 (0.58) | NPC1RAB9AHDAC3L3MBTL1PTGS2 | |
| SCHEMBL10785014 | 0.78 | ALDH1A1 (0.49) | NPC1RAB9AHDAC3ALDH1A1HPGD | |
| SCHEMBL143432 | 0.78 | ALDH1A1 (0.49) | NPC1RAB9AHDAC3ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104204136-B | Indolo [2,1-a ] quinazoline derivatives for stabilizing organic materials | 巴斯夫欧洲公司 | 2016-12-28 | — | — | CN | disclosed |
| EP-2828353-B1 | ISOINDOLO[2,1-A]QUINAZOLINE DERIVATIVES FOR STABILIZATION OF ORGANIC MATERIALS | BASF SE (DE) | 2016-05-18 | — | — | EP | disclosed |
| EP-2828353-B1 | ISOINDOLO[2,1-A]QUINAZOLINE DERIVATIVES FOR STABILIZATION OF ORGANIC MATERIALS | BASF SE (DE) | 2016-05-18 | — | — | EP | disclosed |
| US-9321902-B2 | Isoindolo[2, 1-A]quinazoline derivatives for stabilization of organic materials | BASF SE (DE) | 2016-04-26 | — | — | US | disclosed |
| US-9321902-B2 | Isoindolo[2, 1-A]quinazoline derivatives for stabilization of organic materials | BASF SE (DE) | 2016-04-26 | — | — | US | disclosed |
| US-9321902-B2 | Isoindolo[2, 1-A]quinazoline derivatives for stabilization of organic materials | BASF SE (DE) | 2016-04-26 | — | — | US | disclosed |
| US-20150087755-A1 | ISOINDOLO[2, 1-A]QUINAZOLINE DERIVATIVES FOR STABILIZATION OF ORGANIC MATERIALS | BASF SE (DE) | 2015-03-26 | — | — | US | disclosed |
| US-20150087755-A1 | ISOINDOLO[2, 1-A]QUINAZOLINE DERIVATIVES FOR STABILIZATION OF ORGANIC MATERIALS | BASF SE (DE) | 2015-03-26 | — | — | US | disclosed |
| US-20150087755-A1 | ISOINDOLO[2, 1-A]QUINAZOLINE DERIVATIVES FOR STABILIZATION OF ORGANIC MATERIALS | BASF SE (DE) | 2015-03-26 | — | — | US | disclosed |
| EP-2828353-A1 | ISOINDOLO[2,1-A]QUINAZOLINE DERIVATIVES FOR STABILIZATION OF ORGANIC MATERIALS | BASF SE (DE) | 2015-01-28 | — | — | EP | disclosed |
| US-20100144588-A1 | PROTON ACCEPTOR IMINIUM/CARBOCATION-TYPE COUPLING AGENTS | LUXEMBOURG BIO TECHNOLOGIES LTD. (IL) | 2010-06-10 | — | — | US | disclosed |
| US-20100144588-A1 | PROTON ACCEPTOR IMINIUM/CARBOCATION-TYPE COUPLING AGENTS | LUXEMBOURG BIO TECHNOLOGIES LTD. (IL) | 2010-06-10 | — | — | US | disclosed |
| EP-2170822-A2 | PROTON ACCEPTOR IMINIUM/CARBOCATION-TYPE COUPLING AGENTS | Luxembourg Bio Technologies Ltd. (IL) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009138985-A2 | COUPLING AGENTS FOR THE SYNTHESIS OF POLYPEPTIDES AND POLYNUCLEOTIDES | LUXEMBOURG BIO TECHNOLOGIES LTD. (IL) | 2009-11-19 | — | — | WO | disclosed |
| WO-2009138985-A2 | COUPLING AGENTS FOR THE SYNTHESIS OF POLYPEPTIDES AND POLYNUCLEOTIDES | LUXEMBOURG BIO TECHNOLOGIES LTD. (IL) | 2009-11-19 | — | — | WO | disclosed |
| WO-2008139481-A2 | PROTON ACCEPTOR IMINIUM/CARBOCATION-TYPE COUPLING AGENTS | LUXEMBOURG BIO TECHNOLOGIES LTD. (IL) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008139481-A2 | PROTON ACCEPTOR IMINIUM/CARBOCATION-TYPE COUPLING AGENTS | LUXEMBOURG BIO TECHNOLOGIES LTD. (IL) | 2008-11-20 | — | — | WO | disclosed |
| US-20020082268-A1 | Therapeutic compounds for the treatment of asthma and allergy, and methods of use thereof | SEPRACOR INC. | 2002-06-27 | — | — | US | disclosed |
| WO-2001070737-A2 | THERAPEUTIC HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF ASTHMA AND ALLERGY AND USE THEREOF | SEPRACOR, INC. (US) | 2001-09-27 | — | — | WO | disclosed |
| US-6274383-B1 | REACTING AN AMINO BOUND TO A SOLID SUPPORT WITH AN ISATOIC ANHYDRIDE TO FORM A 2-AMINOBENZAMIDE BOUND TO THE SUPPORT, AND THEN REACTING WITH ALDEHYDE USING A LEWIS ACID CATALYST TO FORM A 2,3-DIHYDRO-4(1H)-QUINAZOLINONE BOUND TO SUPPORT | SEPRACOR INC. | 2001-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150087755-A1 | ISOINDOLO[2, 1-A]QUINAZOLINE DERIVATIVES FOR STABILIZATION OF ORGANIC MATERIALS | SQLE, MYC, CYP4Z1 | NPC1 573/4885RAB9A 2760/4885HDAC3 3963/4885 |
| US-20100144588-A1 | PROTON ACCEPTOR IMINIUM/CARBOCATION-TYPE COUPLING AGENTS | PHAX, GIPR, IAPP | NPC1 3699/4885RAB9A 1625/4885HDAC3 4790/4885 |
| US-20020082268-A1 | Therapeutic compounds for the treatment of asthma and allergy, and methods of use thereof | LTC4S, LTA4H, HRH2 | NPC1 2272/4885RAB9A 2823/4885HDAC3 2633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.