Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.59 |
| ▸ | RAB9A | P51151 | 8/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956547 | 0.84 | RAB9A (0.68) | NPC1RAB9APTGS2KDM4EKMT2A | |
| SCHEMBL1715458 | 0.81 | POLB (0.60) | NPC1RAB9APTGS2POLBMEN1 | |
| SCHEMBL28681431 | 0.80 | PTGS2 (0.64) | NPC1RAB9APTGS2ATMKDM4E | |
| SCHEMBL1715384 | 0.80 | KDR (0.52) | NPC1RAB9APTGS2KDM4EPOLB | |
| SCHEMBL3636008 | 0.80 | NPC1 (0.65) | NPC1RAB9APTGS2KDM4EL3MBTL1 | |
| SCHEMBL28893760 | 0.80 | NPC1 (0.65) | NPC1RAB9APTGS2ATMKDM4E | |
| SCHEMBL1714602 | 0.79 | NPC1 (0.52) | NPC1RAB9APTGS2ATMKDM4E | |
| SCHEMBL1715854 | 0.79 | KDM6B (0.53) | NPC1RAB9APTGS2KDM4EPOLB | |
| SCHEMBL24013287 | 0.78 | ALDH1A1 (0.63) | NPC1RAB9AATMKDM4EPOLB | |
| SCHEMBL1715827 | 0.78 | NPC1 (0.48) | NPC1RAB9APTGS2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274383-B1 | REACTING AN AMINO BOUND TO A SOLID SUPPORT WITH AN ISATOIC ANHYDRIDE TO FORM A 2-AMINOBENZAMIDE BOUND TO THE SUPPORT, AND THEN REACTING WITH ALDEHYDE USING A LEWIS ACID CATALYST TO FORM A 2,3-DIHYDRO-4(1H)-QUINAZOLINONE BOUND TO SUPPORT | SEPRACOR INC. | 2001-08-14 | — | — | US | disclosed |