Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7613082 | 0.85 | MPO (0.51) | MPOGRIK1MEN1KMT2AGPR35 | |
| SCHEMBL27760010 | 0.82 | DGAT1 (0.41) | MPODGAT1GRIK1CES2MEN1 | |
| SCHEMBL5606524 | 0.81 | CES2 (0.50) | CES2MAPTMEN1KMT2ARECQL | |
| SCHEMBL27657555 | 0.80 | DGAT1 (0.39) | DGAT1SIRT2 | |
| SCHEMBL27721413 | 0.79 | P2RX1 (0.43) | CES2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL27742328 | 0.78 | P2RX1 (0.44) | MPOGRIK1CES2MEN1KMT2A | |
| SCHEMBL6772436 | 0.78 | GPR35 (0.41) | MPOGRIK1CTSLMAPTMEN1 | |
| SCHEMBL31337191 | 0.78 | GPR35 (0.41) | MPOGRIK1CTSLMAPTMEN1 | |
| SCHEMBL28217598 | 0.77 | PTGIR (0.46) | CES2MAPTMEN1KMT2AKIF11 | |
| SCHEMBL27653559 | 0.75 | BAZ2B (0.40) | CES2MAPTALDH1A1KIF11EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | disclosed |