Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyrimidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 4/20 | 0.31 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrimidine SCHEMBL28664 | 0.91 | TSHR (0.33) | — | |
| Pyrimidine SCHEMBL988740 | 0.91 | FDPS (0.34) | FDPSBTN3A1PDE3A | |
| Pyrimidine SCHEMBL28492203 | 0.91 | TSHR (0.33) | — | |
| Pyrimidine SCHEMBL454436 | 0.91 | FDPS (0.34) | FDPSBTN3A1PDE3A | |
| Pyrimidine SCHEMBL4140222 | 0.91 | FDPS (0.34) | FDPSBTN3A1PDE3A | |
| Pyrimidine SCHEMBL4154828 | 0.91 | FDPS (0.34) | FDPSBTN3A1PDE3A | |
| Pyrimidine SCHEMBL28436619 | 0.88 | FDPS (0.33) | FDPSBTN3A1PDE3A | |
| Benzene SCHEMBL28827145 | 0.88 | TSHR (0.39) | — | |
| Pyrimidine SCHEMBL27435737 | 0.82 | FFAR3 (0.33) | — | |
| Pyrimidine SCHEMBL28663 | 0.80 | FDPS (0.32) | FDPSBTN3A1PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101674853-B | Amino acid lipids and uses thereof | NASTECH PHARM CO | 2013-03-27 | — | — | CN | disclosed |
| CN-101848642-A | Pesticide compositions | SYNGENTA PARTICIPATIONS AG | 2010-09-29 | — | — | CN | disclosed |
| CN-101674853-A | Amino acid lipids and uses thereof | NASTECH PHARM CO | 2010-03-17 | — | — | CN | disclosed |
| CN-101355970-A | Peptide-DICER substrate RNA conjugates as delivery vehicles for SIRNA | NASTECH PHARM CO (US) | 2009-01-28 | — | — | CN | disclosed |