Pyrimidine — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ADRB3 CYP11B1 DPP4 FGFR1 FGFR2 FGFR3 FGFR4 HRH1 JAK1 JAK2 JAK3 KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 KDR KIT NA OPRD1 OPRK1 OPRM1 P PDGFRB PIK3CD SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SMO TYK2 pol rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Pyrimidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	FDPS	P14324	7/20	0.34

▸	BTN3A1	O00481	1/20	0.33

▸	PDE3A	Q14432	1/20	0.33

▸	TSHR	P16473	1/20	0.33

▸	NAPRT	Q6XQN6	1/20	0.33

▸	TDP1	Q9NUW8	1/20	0.33

▸	ALPL	P05186	1/20	0.31

▸	ALPI	P09923	1/20	0.31

▸	ALPG	P10696	1/20	0.31

▸	HTT	P42858	1/20	0.31

▸	SMN1; SMN2	Q16637	1/20	0.31

▸	CYP2A6	P11509	1/20	0.31

▸	HDAC1	Q13547	1/20	0.30

▸	HDAC6	Q9UBN7	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Pyrimidine SCHEMBL454436	1.00	FDPS (0.34)	FDPSBTN3A1PDE3ATSHRNAPRT
Pyrimidine SCHEMBL4140222	1.00	FDPS (0.34)	FDPSBTN3A1PDE3ATSHRNAPRT
Pyrimidine SCHEMBL988740	1.00	FDPS (0.34)	FDPSBTN3A1PDE3ATSHRNAPRT
Pyrimidine SCHEMBL28436619	0.97	FDPS (0.33)	FDPSBTN3A1PDE3ATSHRNAPRT
Pyrimidine SCHEMBL27748802	0.91	FDPS (0.31)	FDPSBTN3A1PDE3A
Pyrimidine SCHEMBL27549055	0.88	FDPS (0.32)	FDPSBTN3A1PDE3ATSHRNAPRT
Pyrimidine SCHEMBL28663	0.88	FDPS (0.32)	FDPSBTN3A1PDE3ATSHRNAPRT
Pyrimidine SCHEMBL27549056	0.88	FDPS (0.32)	FDPSBTN3A1PDE3ATSHRNAPRT
Pyrimidine SCHEMBL1880807	0.84	FDPS (0.35)	FDPSBTN3A1PDE3AALPLALPI
Foscarnet SCHEMBL15510548	0.83	FDPS (0.33)	FDPSTSHRNAPRTTDP1HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-103031286-B	Cordyceps Chinese Hirsutella uridylate-cytidylate kinase, coding gene and application thereof	UNIV ZHEJIANG TECHNOLOGY	2015-03-18	—	—	CN	claimed
CN-103031287-B	Cordyceps Chinese Hirsutella nucleoside diphosphokinase, coding gene and application thereof	UNIV ZHEJIANG TECHNOLOGY	2014-12-10	—	—	CN	claimed
CN-103045548-A	Cordyceps sinensis ribonucleotide reductase as well as coding gene and application thereof	UNIV ZHEJIANG TECHNOLOGY	2013-04-17	—	—	CN	claimed
CN-103031287-A	Cordyceps Chinese Hirsutella nucleoside diphosphokinase, coding gene and application thereof	UNIV ZHEJIANG TECHNOLOGY	2013-04-10	—	—	CN	claimed
CN-103031286-A	Cordyceps Chinese Hirsutella uridylate-cytidylate kinase, coding gene and application thereof	UNIV ZHEJIANG TECHNOLOGY	2013-04-10	—	—	CN	claimed
US-7612047-B2	Degradation-resistant mononucleoside phosphate compounds	INSPIRE PHARMACEUTICALS, INC. (US)	2009-11-03	—	—	US	claimed
US-20090076256-A1	DEGRADATION-RESISTANT MONONUCLEOSIDE PHOSPHATE COMPOUNDS	DOUGLASS III JAMES G	2009-03-19	—	—	US	claimed
CN-103031286-B	Cordyceps Chinese Hirsutella uridylate-cytidylate kinase, coding gene and application thereof	UNIV ZHEJIANG TECHNOLOGY	2015-03-18	—	—	CN	disclosed
CN-103031287-B	Cordyceps Chinese Hirsutella nucleoside diphosphokinase, coding gene and application thereof	UNIV ZHEJIANG TECHNOLOGY	2014-12-10	—	—	CN	disclosed
CN-103045548-A	Cordyceps sinensis ribonucleotide reductase as well as coding gene and application thereof	UNIV ZHEJIANG TECHNOLOGY	2013-04-17	—	—	CN	disclosed
CN-103031287-A	Cordyceps Chinese Hirsutella nucleoside diphosphokinase, coding gene and application thereof	UNIV ZHEJIANG TECHNOLOGY	2013-04-10	—	—	CN	disclosed
CN-103031286-A	Cordyceps Chinese Hirsutella uridylate-cytidylate kinase, coding gene and application thereof	UNIV ZHEJIANG TECHNOLOGY	2013-04-10	—	—	CN	disclosed
CN-102115485-A	Prodrug based on cytosine arabinoside structure, and synthesis method and application thereof	SANLUGEN PHARMATECH	2011-07-06	—	—	CN	disclosed
CN-1217003-C	Micro array reaction apparatus and uses thereof	CAPTIAL BIOCHIP CO LTD (CN)	2005-08-31	—	—	CN	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20090076256-A1	DEGRADATION-RESISTANT MONONUCLEOSIDE PHOSPHATE COMPOUNDS	PNKP, ENTPD5, ENPP1	FDPS 184/4885BTN3A1 4600/4885PDE3A 2499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.