Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Pyrimidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 7/20 | 0.33 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | ALPI | P09923 | 1/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrimidine SCHEMBL4154828 | 0.97 | FDPS (0.34) | FDPSBTN3A1PDE3ATSHRNAPRT | |
| Pyrimidine SCHEMBL454436 | 0.97 | FDPS (0.34) | FDPSBTN3A1PDE3ATSHRNAPRT | |
| Pyrimidine SCHEMBL4140222 | 0.97 | FDPS (0.34) | FDPSBTN3A1PDE3ATSHRNAPRT | |
| Pyrimidine SCHEMBL988740 | 0.97 | FDPS (0.34) | FDPSBTN3A1PDE3ATSHRNAPRT | |
| Pyrimidine SCHEMBL27748802 | 0.88 | FDPS (0.31) | FDPSBTN3A1PDE3A | |
| Pyrimidine SCHEMBL27549056 | 0.85 | FDPS (0.32) | FDPSBTN3A1PDE3ATSHRNAPRT | |
| Pyrimidine SCHEMBL28663 | 0.85 | FDPS (0.32) | FDPSBTN3A1PDE3ATSHRNAPRT | |
| Pyrimidine SCHEMBL27549055 | 0.85 | FDPS (0.32) | FDPSBTN3A1PDE3ATSHRNAPRT | |
| Pyrimidine SCHEMBL1880807 | 0.82 | FDPS (0.35) | FDPSBTN3A1PDE3AALPLALPI | |
| Pyrophosphoric Acid SCHEMBL3175309 | 0.80 | FDPS (0.53) | FDPSTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111377950-B | Phosphoric acid-pyrimidine zinc dichloride complex with catalytic performance and preparation method and application thereof | 江苏理工学院 | 2022-05-17 | — | — | CN | claimed |
| CN-111377950-A | Phosphoric acid-pyrimidine zinc dichloride complex with catalytic performance and preparation method and application thereof | 江苏理工学院 | 2020-07-07 | — | — | CN | claimed |
| CN-111377950-B | Phosphoric acid-pyrimidine zinc dichloride complex with catalytic performance and preparation method and application thereof | 江苏理工学院 | 2022-05-17 | — | — | CN | disclosed |
| CN-111377950-B | Phosphoric acid-pyrimidine zinc dichloride complex with catalytic performance and preparation method and application thereof | 江苏理工学院 | 2022-05-17 | — | — | CN | disclosed |
| CN-111377950-B | Phosphoric acid-pyrimidine zinc dichloride complex with catalytic performance and preparation method and application thereof | 江苏理工学院 | 2022-05-17 | — | — | CN | disclosed |
| CN-111377950-A | Phosphoric acid-pyrimidine zinc dichloride complex with catalytic performance and preparation method and application thereof | 江苏理工学院 | 2020-07-07 | — | — | CN | disclosed |
| CN-111377950-A | Phosphoric acid-pyrimidine zinc dichloride complex with catalytic performance and preparation method and application thereof | 江苏理工学院 | 2020-07-07 | — | — | CN | disclosed |
| CN-111377950-A | Phosphoric acid-pyrimidine zinc dichloride complex with catalytic performance and preparation method and application thereof | 江苏理工学院 | 2020-07-07 | — | — | CN | disclosed |