Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 3/20 | 0.31 |
| ▸ | CA1 | P00915 | 3/20 | 0.31 |
| ▸ | CA2 | P00918 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29600745 | 0.80 | TP53 (0.31) | CA12CA1CA2CA9CA14 | |
| SCHEMBL9045453 | 0.80 | KDM4E (0.40) | LMNAKDM4EHPGDTSHRCA12 | |
| SCHEMBL5660573 | 0.77 | HDAC2 (0.31) | — | |
| SCHEMBL2301074 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL10438113 | 0.74 | BLM (0.41) | LMNATHRBBLMMAPK1TSHR | |
| Hydrochloric Acid SCHEMBL17597680 | 0.74 | BLM (0.41) | LMNATHRBBLMMAPK1TSHR | |
| SCHEMBL1017726 | 0.74 | — | — | |
| SCHEMBL13018296 | 0.73 | MMP1 (0.34) | KDM4EMAPK1GAA | |
| SCHEMBL22411680 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL30468940 | 0.72 | THRB (0.36) | THRBBLMMAPK1TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023169336-A1 | PYRIDAZINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | 成都科岭源医药技术有限公司 | 2023-09-14 | — | — | WO | disclosed |
| CN-110041316-A | TAM family kinase/and CSF1R kinase inhibitor and application thereof | 南京药捷安康生物科技有限公司 | 2019-07-23 | — | — | CN | disclosed |
| CN-105541833-B | Derivative of the dihydropyridine of pyridiniujm/1,4 and preparation method thereof | 华东理工大学 | 2018-02-16 | — | — | CN | disclosed |
| CN-106478496-A | Dihydropyridine sulfonamide and dihydropyridine sulphamide as mek inhibitor | 阿迪生物科学公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-105683191-A | Protein kinase inhibitor containing pyrrolopyridazine derivative | CJ医药健康株式会社 | 2016-06-15 | — | — | CN | disclosed |
| CN-101511789-B | 5, 6-bisaryl-2-pyridine-carboxamide derivatives, their preparation and their use in therapy as urotensin II receptor antagonists | SANOFI AVENTIS | 2012-05-23 | — | — | CN | disclosed |
| CN-102105462-A | Amidophenoxyindazoles useful as inhibitors of C-MET | LILLY CO ELI | 2011-06-22 | — | — | CN | disclosed |
| CN-101896227-A | Combination comprising an MEK inhibitor and an aurora kinase inhibitor | ASTRAZENECA AB | 2010-11-24 | — | — | CN | disclosed |
| CN-101511789-A | 5, 6-bisaryl-2-pyridine-carboxamide derivatives, their preparation and their use in therapy as urotensin II receptor antagonists | SANOFI AVENTIS (FR) | 2009-08-19 | — | — | CN | disclosed |