Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA7 | P43166 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24157626 | 0.76 | LMNA (0.36) | KDM4EKMT2AMEN1MAPTLMNA | |
| SCHEMBL29600745 | 0.76 | TP53 (0.31) | MAPTALOX15CA12CA1CA2 | |
| SCHEMBL8947546 | 0.74 | TSHR (0.48) | KDM4EKMT2AMEN1MAPTALOX15 | |
| SCHEMBL28417053 | 0.74 | TSHR (0.48) | KDM4EKMT2AMEN1MAPTALOX15 | |
| SCHEMBL13981346 | 0.72 | CHRNB2 (0.55) | — | |
| SCHEMBL9039761 | 0.71 | TSHR (0.46) | KDM4EKMT2AMEN1MAPTALOX15 | |
| SCHEMBL28221804 | 0.71 | MEN1 (0.39) | KDM4EKMT2AMEN1MAPTALOX15 | |
| SCHEMBL5187673 | 0.70 | TSHR (0.40) | KDM4EKMT2AMEN1MAPTALOX15 | |
| SCHEMBL28326634 | 0.69 | TSHR (0.39) | KDM4EKMT2AMEN1MAPTALOX15 | |
| SCHEMBL16863288 | 0.69 | KMT2A (0.40) | KDM4EKMT2AMEN1MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020042618-A1 | MULTI-SUBSTITUTED PYRIDONE DERIVATIVES AND MEDICAL USE THEREOF | 北京越之康泰生物医药科技有限公司 | 2020-03-05 | — | — | WO | disclosed |
| CN-108025002-A | Six-membered azaheterocyclic containing opioid receptor modulating compounds, methods of use and preparation thereof | 特维娜有限公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-102762548-B | Isoindolinone inhibitors of phosphatidylinositol 3-kinase | VERTEX PHARMA | 2014-11-26 | — | — | CN | disclosed |
| CN-101263133-A | New pyridine analogues | ASTRAZENECA AB (SE) | 2008-09-10 | — | — | CN | disclosed |
| EP-0471609-B1 | Benzofuran Derivatives, Benzothiophenes, Indoles or Indolizines, Process for Production and Compositions containing them | SANOFI SA (FR) | 1996-11-27 | — | — | EP | disclosed |
| EP-0471609-A1 | Benzofuran Derivatives, Benzothiophenes, Indoles or Indolizines, Process for Production and Compositions containing them | SANOFI (FR) | 1992-02-19 | — | — | EP | disclosed |