Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27230835 | 0.82 | ALDH1A1 (0.41) | NOTUMPTGS1PTGS2ALDH1A1PPARG | |
| SCHEMBL31085235 | 0.80 | LMNA (0.44) | KMONOTUMHDAC4HDAC2HDAC8 | |
| SCHEMBL15566600 | 0.80 | HTR2C (0.43) | KMONOTUMHDAC4HDAC2HDAC8 | |
| SCHEMBL26816768 | 0.78 | NOTUM (0.43) | KMONOTUMHDAC4HDAC2HDAC8 | |
| SCHEMBL22284242 | 0.78 | PPARG (0.49) | RECQLLMNAROCK2PRKG1PPARG | |
| SCHEMBL23380258 | 0.78 | NOTUM (0.52) | KMONOTUMHDAC4HDAC2HDAC8 | |
| SCHEMBL22284241 | 0.78 | PPARG (0.49) | RECQLLMNAROCK2PRKG1PPARG | |
| SCHEMBL6221411 | 0.77 | HTR2C (0.51) | — | |
| SCHEMBL20931702 | 0.77 | HTR2C (0.41) | KMONOTUMHDAC4HDAC2HDAC8 | |
| SCHEMBL14157609 | 0.77 | HTR2C (0.41) | KMONOTUMHDAC4HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101384580-A | Cyclic sulfones useful as BACE inhibitors | NOVARTIS AG (CH) | 2009-03-11 | — | — | CN | disclosed |