Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GRIA2 | P42262 | 8/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 6/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 6/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2775615 | 0.84 | GRIA2 (0.40) | NPSR1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL5349703 | 0.79 | NPSR1 (0.50) | NPSR1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL2776877 | 0.78 | KMT2A (0.37) | NPSR1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL2776459 | 0.76 | GRIA2 (0.48) | NPSR1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL29437629 | 0.75 | GRIA2 (0.45) | NPSR1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL28433292 | 0.75 | GRIA2 (0.45) | NPSR1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL5358667 | 0.68 | NPSR1 (0.50) | NPSR1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL2778463 | 0.68 | GRIA2 (0.42) | NPSR1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL2778320 | 0.68 | GRIA2 (0.69) | GRIA2GRIA1GRIA3GRIA4ALDH1A1 | |
| SCHEMBL5358301 | 0.67 | GRIA2 (0.43) | NPSR1GRIA2GRIA1GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2147915-B1 | New cycloalkylated benzothiadiazine derivatives, method of preparing same and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-09-15 | — | — | EP | disclosed |
| US-7741320-B2 | Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2010-06-22 | — | — | US | disclosed |
| EP-2147915-A1 | New cycloalkylated benzothiadiazine derivatives, method of preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2010-01-27 | — | — | EP | disclosed |
| US-20100009974-A1 | Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compostions containing them | LES LABORATOIRES SERVIER (FR) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009974-A1 | Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compostions containing them | ACLY, HCAR1, GABRG1 | NPSR1 72/4885GRIA2 116/4885GRIA1 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.