Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | APP | P05067 | 5/20 | 0.52 |
| ▸ | SNCA | P37840 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28129799 | 0.82 | MAOB (0.43) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL16427344 | 0.80 | KDR (0.49) | MAOBMAOAPIM1PIM2 | |
| SCHEMBL16427343 | 0.80 | KDR (0.49) | MAOBMAOAPIM1PIM2 | |
| SCHEMBL16426717 | 0.80 | MAOB (0.48) | MAOBMAOAPIM1PIM2 | |
| SCHEMBL16426716 | 0.80 | MAOB (0.48) | MAOBMAOAPIM1PIM2 | |
| SCHEMBL16426758 | 0.77 | RAB9A (0.55) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL16426757 | 0.77 | RAB9A (0.55) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL16426515 | 0.76 | ELANE (0.43) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL16426516 | 0.76 | ELANE (0.43) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL15291319 | 0.71 | JAK2 (0.39) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101495147-B | Pharmaceutical combinations. | NOVARTIS AG | 2012-01-25 | — | — | CN | disclosed |
| CN-101495147-A | Pharmaceutical combinations. | NOVARTIS AG (CH) | 2009-07-29 | — | — | CN | disclosed |