Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMDHD2 | Q9Y303 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | BDNF | P23560 | 3/20 | 0.40 |
| ▸ | PTN | P21246 | 2/20 | 0.40 |
| ▸ | MDK | P21741 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HK1 | P19367 | 3/20 | 0.37 |
| ▸ | HK2 | P52789 | 3/20 | 0.37 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15966272 | 0.95 | MAPK1 (0.45) | AMDHD2MAPK1BDNFPTNMDK | |
| SCHEMBL30089326 | 0.95 | MAPK1 (0.45) | AMDHD2MAPK1BDNFPTNMDK | |
| SCHEMBL15965653 | 0.95 | MAPK1 (0.45) | AMDHD2MAPK1BDNFPTNMDK | |
| SCHEMBL22362645 | 0.95 | MAPK1 (0.45) | AMDHD2MAPK1BDNFPTNMDK | |
| SCHEMBL17689074 | 0.95 | MAPK1 (0.45) | AMDHD2MAPK1BDNFPTNMDK | |
| SCHEMBL23631128 | 0.95 | MAPK1 (0.45) | AMDHD2MAPK1BDNFPTNMDK | |
| SCHEMBL15966248 | 0.95 | MAPK1 (0.45) | AMDHD2MAPK1BDNFPTNMDK | |
| SCHEMBL20474503 | 0.95 | MAPK1 (0.45) | AMDHD2MAPK1BDNFPTNMDK | |
| SCHEMBL20415021 | 0.83 | BDNF (0.38) | MAPK1BDNFPTNMDKALDH1A1 | |
| SCHEMBL29406391 | 0.83 | HPSE (0.45) | AMDHD2MAPK1ALDH1A1THRBCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101405008-A | Gene therapy for niemann-pick disease type A | GENZYME CORP (US) | 2009-04-08 | — | — | CN | disclosed |