Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | TSHR | P16473 | 7/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27739696 | 0.85 | AURKA (0.45) | ADORA3ADORA2AADORA1AURKARPS6KB1 | |
| SCHEMBL5456441 | 0.84 | KDM4E (0.52) | KDM4ELMNATP53MAPTMAPK1 | |
| SCHEMBL17865952 | 0.83 | KDM4E (0.48) | KDM4ELMNATP53MAPTMAPK1 | |
| SCHEMBL17865943 | 0.79 | KDM4E (0.47) | KDM4ELMNATP53MAPTMAPK1 | |
| SCHEMBL17865941 | 0.79 | NAE1 (0.49) | KDM4ELMNATP53MAPTMAPK1 | |
| SCHEMBL191796 | 0.78 | NAE1 (0.63) | KDM4ELMNATP53MAPTAURKA | |
| SCHEMBL10235267 | 0.76 | NAE1 (0.47) | KDM4ELMNATP53MAPTMAPK1 | |
| SCHEMBL21283384 | 0.75 | UBA6 (0.46) | KDM4ELMNATP53MAPTMAPK1 | |
| SCHEMBL16414565 | 0.72 | PRMT5 (0.43) | — | |
| SCHEMBL22400280 | 0.70 | NAE1 (0.61) | AURKARPS6KB1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101379061-A | E1 activating enzyme inhibitor | MILLENNIUM PHARM INC (US) | 2009-03-04 | — | — | CN | disclosed |