Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | MPO | P05164 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27882430 | 0.84 | ATM (0.51) | ATMMPOALDH1A1CYP1A2HPGD | |
| SCHEMBL27745442 | 0.80 | ATM (0.44) | ATMMPOALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL28107665 | 0.79 | MPO (0.71) | ATMMPOALDH1A1HPGDKDM4E | |
| SCHEMBL28799922 | 0.79 | ATM (0.46) | ATMMPOALDH1A1CYP1A2HPGD | |
| SCHEMBL27654482 | 0.76 | MPO (0.65) | MPOALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL27882435 | 0.75 | BCHE (0.46) | ATMMPONPC1RAB9A | |
| SCHEMBL27763783 | 0.74 | MAPT (0.55) | ATMMPOSMN1; SMN2MAPTRECQL | |
| SCHEMBL3592059 | 0.73 | PTGER4 (0.48) | ATMALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL205462 | 0.73 | MPO (0.60) | ATMMPOALDH1A1CYP1A2HPGD | |
| SCHEMBL29092663 | 0.73 | BRD4 (0.47) | ATMMPOKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101558057-B | 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders | ACRAF | 2013-05-01 | — | — | CN | disclosed |
| CN-101558057-A | 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders | ACRAF (IT) | 2009-10-14 | — | — | CN | disclosed |