Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27882430 | 0.81 | ATM (0.51) | ATMMPOALDH1A1NPC1RAB9A | |
| SCHEMBL27763782 | 0.79 | ATM (0.51) | ATMMPOALDH1A1NPC1RAB9A | |
| SCHEMBL28799923 | 0.75 | SRC (0.37) | ATMMPOSMN1; SMN2PTGER4SRC | |
| SCHEMBL27745442 | 0.74 | ATM (0.44) | ATMMPOALDH1A1NPC1RAB9A | |
| SCHEMBL27882435 | 0.72 | BCHE (0.46) | ATMMPONPC1RAB9AMEN1 | |
| SCHEMBL27654482 | 0.68 | MPO (0.65) | MPOALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL205462 | 0.65 | MPO (0.60) | ATMMPOALDH1A1HPGDCYP2C9 | |
| SCHEMBL18073164 | 0.62 | MPO (0.91) | ATMMPOALDH1A1HPGDCYP2C9 | |
| SCHEMBL17981714 | 0.62 | MPO (0.46) | ATMMPOALDH1A1PTGER4KDM4E | |
| SCHEMBL27669281 | 0.62 | PTGER4 (0.50) | ALDH1A1SMN1; SMN2HPGDPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102812028-B | Tricyclic indazole compounds, process for their preparation and pharmaceutical compositions containing them | ACRAF | 2014-11-12 | — | — | CN | disclosed |
| CN-102812028-A | Tricyclic indazole compounds, process for their preparation and pharmaceutical compositions containing them | ACRAF | 2012-12-05 | — | — | CN | disclosed |