Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | NEK2 | P51955 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27745442 | 0.80 | ATM (0.44) | MPOALDH1A1NPSR1RAB9ANPC1 | |
| SCHEMBL27763782 | 0.76 | ATM (0.51) | MPOALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL6416275 | 0.73 | MEN1 (0.58) | MPOALDH1A1HPGDLMNAMAPT | |
| SCHEMBL9593922 | 0.72 | LMNA (0.67) | ALDH1A1HPGDLMNAMAPTNPSR1 | |
| SCHEMBL27882430 | 0.72 | ATM (0.51) | MPOALDH1A1HPGDGAARAB9A | |
| SCHEMBL6411455 | 0.72 | CHEK1 (0.68) | MPOALDH1A1ESR2GAACHEK1 | |
| SCHEMBL27783210 | 0.72 | MPO (0.45) | MPOALDH1A1ADORA3ADORA2AESR2 | |
| SCHEMBL29161027 | 0.70 | CHEK1 (0.56) | MPOALDH1A1HPGDADORA3ADORA2A | |
| SCHEMBL1921784 | 0.70 | MPO (0.46) | MPOALDH1A1HPGDADORA3ADORA2A | |
| SCHEMBL23320433 | 0.70 | MPO (0.49) | MPOALDH1A1HPGDLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826319-A | Aryl-heteroaromatic compounds, compositions comprising them and use | AVENTIS PHARMA (FR) | 2006-08-30 | — | — | CN | disclosed |