Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 11/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27654482 | 0.80 | MPO (0.65) | MPONPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL27763782 | 0.80 | ATM (0.51) | ATMMPONPC1ALDH1A1RAB9A | |
| SCHEMBL27882430 | 0.79 | ATM (0.51) | ATMMPONPC1ALDH1A1RAB9A | |
| SCHEMBL20132949 | 0.77 | MPO (0.61) | ATMMPOALDH1A1 | |
| SCHEMBL27615502 | 0.76 | GRM2 (0.37) | ALDH1A1SMN1; SMN2NPSR1SLC22A6 | |
| SCHEMBL28799922 | 0.74 | ATM (0.46) | ATMMPONPC1ALDH1A1RAB9A | |
| SCHEMBL17324739 | 0.74 | KDM5A (0.42) | ATMNPC1ALDH1A1RAB9AKDM5A | |
| SCHEMBL3712946 | 0.74 | MPO (0.45) | ATMMPO | |
| SCHEMBL1563562 | 0.70 | KDM5A (0.48) | ALDH1A1SMN1; SMN2KDM5AKDM4CKDM5B | |
| SCHEMBL1562180 | 0.70 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KDM5AKDM4CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101558057-B | 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders | ACRAF | 2013-05-01 | — | — | CN | disclosed |
| CN-101558057-A | 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders | ACRAF (IT) | 2009-10-14 | — | — | CN | disclosed |
| CN-101466703-A | Heterocyclic GABA-alpha subtype selective receptor modulators | HOFFMANN LA ROCHE (CH) | 2009-06-24 | — | — | CN | disclosed |