Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 6/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27765347 | 1.00 | GCK (0.42) | GCKKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27765336 | 0.91 | GCK (0.42) | GCKKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27558109 | 0.82 | GCK (0.47) | GCKKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27578470 | 0.82 | GCK (0.47) | GCKKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27558086 | 0.79 | GCK (0.44) | GCKKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27502236 | 0.77 | KCNH2 (0.46) | GCKKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27467646 | 0.77 | KCNH2 (0.46) | GCKKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1858972 | 0.76 | GCK (0.55) | GCKKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1858970 | 0.76 | GCK (0.55) | GCKKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27616381 | 0.76 | KCNH2 (0.45) | GCKKCNH2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541756-A | Pyrazoles as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2009-09-23 | — | — | CN | disclosed |