Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 8/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27578470 | 0.91 | GCK (0.47) | GCKKCNH2FFAR1SLC6A2SLC6A4 | |
| SCHEMBL27558109 | 0.91 | GCK (0.47) | GCKKCNH2FFAR1SLC6A2SLC6A4 | |
| SCHEMBL27765343 | 0.91 | GCK (0.42) | GCKKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27765347 | 0.91 | GCK (0.42) | GCKKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27558086 | 0.88 | GCK (0.44) | GCKKCNH2FFAR1SLC6A2SLC6A4 | |
| SCHEMBL27467646 | 0.87 | KCNH2 (0.46) | GCKKCNH2FFAR1SLC6A2SLC6A4 | |
| SCHEMBL27502236 | 0.87 | KCNH2 (0.46) | GCKKCNH2FFAR1SLC6A2SLC6A4 | |
| SCHEMBL27575894 | 0.81 | ALDH1A1 (0.43) | GCKKCNH2PTGDRTBXA2RPDE2A | |
| SCHEMBL28749510 | 0.80 | FFAR1 (0.39) | GCKKCNH2FFAR1SLC6A2SLC6A4 | |
| SCHEMBL1864199 | 0.76 | GCK (0.55) | GCKKCNH2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541756-A | Pyrazoles as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2009-09-23 | — | — | CN | disclosed |