Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 8/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27765605 | 0.85 | PTGS2 (0.59) | FGFR1FGFR2FGFR3ESR1ESR2 | |
| SCHEMBL30648021 | 0.84 | CA2 (0.50) | CDK5CDK5R1MEN1KMT2A | |
| SCHEMBL93623 | 0.84 | CA2 (0.50) | CDK5CDK5R1MEN1KMT2A | |
| SCHEMBL13541757 | 0.83 | TNKS2 (0.49) | FGFR1ESR1ESR2CDK5CDK5R1 | |
| SCHEMBL20615410 | 0.81 | TNKS2 (0.50) | FGFR1FGFR2FGFR3PTGS2 | |
| SCHEMBL18000095 | 0.80 | PDE3B (0.50) | — | |
| SCHEMBL28548436 | 0.79 | AXL (0.59) | ESR2HSD17B1HSD17B2 | |
| SCHEMBL28561888 | 0.77 | MAPT (0.46) | PTGS2 | |
| SCHEMBL27765642 | 0.76 | ESR2 (0.51) | ESR2DHODHMEN1KMT2A | |
| SCHEMBL20494223 | 0.74 | SMAD3 (0.60) | FGFR1FGFR2FGFR3ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541801-A | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL (JP) | 2009-09-23 | — | — | CN | disclosed |