Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27919673 | 0.92 | L3MBTL3 (0.45) | L3MBTL1L3MBTL3HRH3SIGMAR1TLR7 | |
| SCHEMBL27901897 | 0.91 | L3MBTL3 (0.44) | L3MBTL1L3MBTL3HRH3SIGMAR1 | |
| SCHEMBL27789439 | 0.91 | NOS3 (0.46) | NOS3NOS1NOS2HRH3SIGMAR1 | |
| SCHEMBL27901891 | 0.83 | HRH3 (0.41) | NOS3NOS1NOS2HRH3SIGMAR1 | |
| SCHEMBL27789434 | 0.82 | CYP1A2 (0.42) | NOS3NOS1NOS2HRH3 | |
| SCHEMBL27767887 | 0.81 | F12 (0.37) | NOS3NOS1NOS2HRH3TLR7 | |
| SCHEMBL27901890 | 0.80 | HRH3 (0.38) | HRH3SIGMAR1TLR7 | |
| SCHEMBL27789440 | 0.80 | SIGMAR1 (0.44) | HRH3SIGMAR1TLR7 | |
| SCHEMBL28784755 | 0.80 | ACVR1 (0.33) | L3MBTL1ACVR1KDM4ERAD52MAPT | |
| SCHEMBL27768013 | 0.80 | ACVR1 (0.33) | L3MBTL1ACVR1KDM4ERAD52MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101622248-B | N3-heteroaryl substituted triazoles and n5-heteroaryl substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS INC | 2013-04-17 | — | — | CN | claimed |
| CN-101622248-A | N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS INC | 2010-01-06 | — | — | CN | claimed |
| CN-101622248-B | N3-heteroaryl substituted triazoles and n5-heteroaryl substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS INC | 2013-04-17 | — | — | CN | disclosed |
| CN-101622248-A | N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS INC | 2010-01-06 | — | — | CN | disclosed |