Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.48 |
| ▸ | RAB9A | P51151 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.48 |
| ▸ | NPC1 | O15118 | 9/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27768288 | 0.81 | ALDH1A1 (0.46) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3609848 | 0.79 | RAB9A (0.59) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3604832 | 0.78 | MAPT (0.78) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3602577 | 0.76 | KLK7 (0.69) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3603474 | 0.76 | RAB9A (0.71) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3607158 | 0.76 | RAB9A (0.75) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3604856 | 0.72 | MAPT (0.52) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL10663004 | 0.71 | MAPT (0.66) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3610538 | 0.70 | ALDH1A1 (0.54) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3598355 | 0.69 | ALDH1A1 (0.69) | MAPTRAB9AALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466692-A | Thiazol-guanidine derivatives useful as a (beta) - related pathologies | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | claimed |
| CN-101466692-A | Thiazol-guanidine derivatives useful as a (beta) - related pathologies | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | disclosed |