Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.46 |
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27768178 | 0.81 | MAPT (0.48) | ALDH1A1MAPTSMN1; SMN2HTTNPSR1 | |
| SCHEMBL3610538 | 0.80 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2HTTNR2F2 | |
| SCHEMBL3598355 | 0.79 | ALDH1A1 (0.69) | ALDH1A1MAPTSMN1; SMN2HTTNR2F2 | |
| SCHEMBL3604493 | 0.78 | NPC1 (0.54) | ALDH1A1MAPTSMN1; SMN2HTTNR2F2 | |
| SCHEMBL3608764 | 0.78 | ALDH1A1 (0.61) | ALDH1A1MAPTSMN1; SMN2HTTNR2F2 | |
| SCHEMBL3609848 | 0.71 | RAB9A (0.59) | ALDH1A1MAPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL3604832 | 0.71 | MAPT (0.78) | ALDH1A1MAPTSMN1; SMN2HTTNR2F2 | |
| SCHEMBL3607158 | 0.69 | RAB9A (0.75) | ALDH1A1MAPTSMN1; SMN2HTTNPSR1 | |
| SCHEMBL3603474 | 0.69 | RAB9A (0.71) | ALDH1A1MAPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL3602577 | 0.69 | KLK7 (0.69) | ALDH1A1MAPTSMN1; SMN2LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466692-A | Thiazol-guanidine derivatives useful as a (beta) - related pathologies | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | claimed |
| CN-101466692-A | Thiazol-guanidine derivatives useful as a (beta) - related pathologies | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | disclosed |