Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.78 |
| ▸ | RAB9A | P51151 | 6/20 | 0.78 |
| ▸ | MEN1 | O00255 | 5/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.78 |
| ▸ | NPC1 | O15118 | 5/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | USP2 | O75604 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | CDC25A | P30304 | 3/20 | 0.58 |
| ▸ | CDC25B | P30305 | 3/20 | 0.58 |
| ▸ | CDC25C | P30307 | 3/20 | 0.58 |
| ▸ | DUSP3 | P51452 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3609848 | 0.83 | RAB9A (0.59) | MAPTALDH1A1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL14434535 | 0.83 | MAPT (0.76) | MAPTALDH1A1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL3598355 | 0.81 | ALDH1A1 (0.69) | MAPTALDH1A1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL3604660 | 0.81 | ALDH1A1 (0.58) | MAPTALDH1A1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL17549353 | 0.81 | MAPT (0.72) | MAPTALDH1A1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL3602577 | 0.80 | KLK7 (0.69) | MAPTALDH1A1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL3603474 | 0.80 | RAB9A (0.71) | MAPTALDH1A1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL3607158 | 0.78 | RAB9A (0.75) | MAPTALDH1A1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL27768178 | 0.78 | MAPT (0.48) | MAPTALDH1A1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL8486353 | 0.76 | CDC25A (0.79) | MAPTALDH1A1SMN1; SMN2RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298340-A1 | Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | claimed |
| CN-101466692-A | Thiazol-guanidine derivatives useful as a (beta) - related pathologies | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | claimed |
| US-20100298340-A1 | Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | disclosed |
| CN-101466692-A | Thiazol-guanidine derivatives useful as a (beta) - related pathologies | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298340-A1 | Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies | GRN, MAPT, GUCY1B1 | MAPT 2/4885ALDH1A1 1302/4885SMN1; SMN2 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.