SCHEMBL27768230

SCHEMBL27768230

O=C1C=CC(=O)C(C2C=CCCC2)=C1

nearest known ligand 0.52

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.52
MAOB P27338 1/20 0.52
ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27768231 0.89 MAOA (0.50) MAOAMAOBALDH1A1
SCHEMBL27789731 0.72 LMNA (0.34)
SCHEMBL10994698 0.70 NPC1 (0.30)
SCHEMBL9273561 0.69 MAOA (1.00) MAOAMAOBALDH1A1
SCHEMBL30945992 0.68 MAOA (0.83) MAOAMAOBALDH1A1
SCHEMBL9343961 0.67 MAOA (0.96) MAOAMAOBALDH1A1
SCHEMBL29266041 0.67 MAOA (0.96) MAOAMAOBALDH1A1
SCHEMBL25360241 0.65
SCHEMBL24071089 0.64
SCHEMBL18304604 0.63 CYP2C19 (0.39) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101624332-B Novel compound with antitumor activity and application thereof GUANZHOU INST OF BIOMEDICINE AND HEALTH CHINESE ACADEMY OF SCIENCE 2012-11-21 CN claimed
CN-101624332-A Novel compound with antitumor activity and application thereof GUANZHOU INST OF BIOMEDICINE A 2010-01-13 CN claimed
CN-101624332-B Novel compound with antitumor activity and application thereof GUANZHOU INST OF BIOMEDICINE AND HEALTH CHINESE ACADEMY OF SCIENCE 2012-11-21 CN disclosed
CN-101624332-A Novel compound with antitumor activity and application thereof GUANZHOU INST OF BIOMEDICINE A 2010-01-13 CN disclosed