Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 2/20 | 0.56 |
| ▸ | ATP4B | P51164 | 2/20 | 0.56 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3613607 | 0.92 | LTA4H (0.59) | ATP4AATP4BELOVL1ROCK1ROCK2 | |
| SCHEMBL3598628 | 0.88 | MAPT (0.58) | ELOVL1KDM4EHTTNPC1RAB9A | |
| SCHEMBL3603436 | 0.87 | MEN1 (0.61) | ELOVL1GAAHTTNPC1RAB9A | |
| Bromide SCHEMBL7330009 | 0.86 | MEN1 (0.59) | ELOVL1KDM4EGAAHTTNPC1 | |
| SCHEMBL27768308 | 0.85 | AOC3 (0.50) | ATP4AATP4BELOVL1ROCK1ROCK2 | |
| SCHEMBL2380037 | 0.82 | RAB9A (0.61) | ATP4AATP4BROCK1ROCK2KDM4E | |
| SCHEMBL3607861 | 0.81 | ABL1 (0.47) | ATP4AATP4BELOVL1ROCK1ROCK2 | |
| SCHEMBL4330706 | 0.81 | SCD (0.70) | ROCK1KDM4EGAAHTTNPC1 | |
| SCHEMBL3604799 | 0.80 | ALOX5 (0.61) | ATP4AATP4BROCK1ROCK2AOC3 | |
| SCHEMBL3594785 | 0.80 | MAPT (0.65) | ATP4AATP4BGAAHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466692-A | Thiazol-guanidine derivatives useful as a (beta) - related pathologies | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | claimed |
| CN-101466692-A | Thiazol-guanidine derivatives useful as a (beta) - related pathologies | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | disclosed |