Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.47 |
| ▸ | F10 | P00742 | 4/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.47 |
| ▸ | SCN4A | P35499 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27768099 | 0.83 | PARP1 (0.48) | MEN1KMT2ASCN9A | |
| SCHEMBL3135703 | 0.81 | MCL1 (0.49) | SCN4AMCL1SCN9ANPC1RAB9A | |
| SCHEMBL18335708 | 0.80 | RAB9A (0.58) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL27768368 | 0.80 | F10 (0.47) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL13680556 | 0.77 | MEN1 (0.46) | MEN1KMT2ASCN9ANPC1RAB9A | |
| SCHEMBL27747196 | 0.77 | MEN1 (0.44) | MEN1KMT2AMCL1SCN9ANPC1 | |
| SCHEMBL5799799 | 0.77 | PARP10 (0.64) | MEN1KMT2ANPC1RAB9APARP10 | |
| SCHEMBL16334747 | 0.76 | FFAR4 (0.62) | — | |
| SCHEMBL3140552 | 0.76 | MCL1 (0.44) | SCN4AMCL1SCN9ANPC1RAB9A | |
| SCHEMBL3126744 | 0.75 | SCN9A (0.59) | SCN4AMCL1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466710-B | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC | 2013-05-29 | — | — | CN | disclosed |
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | disclosed |