Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 13/20 | 0.47 |
| ▸ | F2 | P00734 | 10/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B14 | Q9BPX1 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27768102 | 0.83 | TGFBR1 (0.50) | — | |
| SCHEMBL27768366 | 0.80 | F2 (0.47) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL27747197 | 0.77 | ALDH1A1 (0.40) | MEN1KMT2ASCN9A | |
| SCHEMBL27747194 | 0.74 | ALDH1A1 (0.43) | MEN1KMT2ASMN1; SMN2SCN9A | |
| SCHEMBL16511926 | 0.74 | F2 (0.48) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL9629071 | 0.72 | CTNNB1 (0.61) | CTNNB1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4705063 | 0.72 | GRM4 (0.48) | F2KMT2ASMN1; SMN2 | |
| SCHEMBL29728528 | 0.72 | KMT2A (0.46) | CTNNB1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL725893 | 0.70 | OPRM1 (0.62) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL2521152 | 0.70 | LTA4H (0.58) | F10F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466710-B | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC | 2013-05-29 | — | — | CN | disclosed |
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | disclosed |