Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22418886 | 0.83 | GLS (0.46) | LMNAHSD17B10CHRM1GAAKDM4E | |
| SCHEMBL19275401 | 0.81 | CA12 (0.50) | LMNACHRM1ELANEKDM4ECYP1A2 | |
| SCHEMBL818912 | 0.80 | GAA (0.43) | LMNAHSD17B10GAAKDM4ECYP1A2 | |
| SCHEMBL819824 | 0.80 | GLS (0.46) | LMNAHSD17B10CHRM1CYP1A2CYP2D6 | |
| SCHEMBL4352840 | 0.78 | LMNA (0.52) | LMNACHRM1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL27686619 | 0.78 | CYP1A2 (0.43) | LMNACYP1A2CYP2D6PKMSMN1; SMN2 | |
| SCHEMBL16820449 | 0.77 | LMNA (0.56) | LMNAHSD17B10GAASMN1; SMN2NPSR1 | |
| SCHEMBL6410341 | 0.77 | LMNA (0.56) | LMNAHSD17B10GAASMN1; SMN2NPSR1 | |
| SCHEMBL582647 | 0.77 | LMNA (0.56) | LMNAHSD17B10GAASMN1; SMN2NPSR1 | |
| SCHEMBL27808237 | 0.77 | SCN4A (0.49) | CYP1A2CYP2D6PKMSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101636378-A | Malonamides as orexin antagonists | HOFFMANN LA ROCHE | 2010-01-27 | — | — | CN | disclosed |