Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.52 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | FLT1 | P17948 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | CLK2 | P49760 | 2/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.52 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.52 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | FES | P07332 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27748684 | 0.74 | CAMKK2 (0.48) | DYRK1AMAP4K4KDRCLK2CDK5 | |
| SCHEMBL7737770 | 0.74 | PDGFRB (0.44) | DYRK1AJAK2AURKAPRKD3MAP4K4 | |
| SCHEMBL18392230 | 0.70 | DYRK1A (0.54) | DYRK1AJAK2AURKAPRKD3MAP4K4 | |
| SCHEMBL1516750 | 0.69 | JAK2 (1.00) | DYRK1AJAK2AURKAPRKD3MAP4K4 | |
| SCHEMBL11968456 | 0.69 | DYRK1A (0.54) | DYRK1AJAK2AURKAPRKD3MAP4K4 | |
| SCHEMBL31748571 | 0.69 | DYRK1A (0.51) | DYRK1AJAK2AURKAPRKD3MAP4K4 | |
| SCHEMBL28614283 | 0.68 | JAK2 (0.75) | DYRK1AJAK2AURKAPRKD3MAP4K4 | |
| SCHEMBL8320389 | 0.68 | DYRK1A (0.66) | DYRK1AJAK2AURKAPRKD3MAP4K4 | |
| SCHEMBL8324869 | 0.67 | DYRK1A (0.56) | DYRK1AJAK2AURKAPRKD3MAP4K4 | |
| SCHEMBL1516629 | 0.67 | DYRK1A (0.73) | DYRK1AJAK2AURKAPRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101492465-A | 7,7'-diaza indirubin compounds for antineoplastic medicament | UNIV SHANGHAI JIAOTONG (CN) | 2009-07-29 | — | — | CN | disclosed |