Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 4/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28294631 | 0.86 | HDAC1 (0.40) | QDPRHDAC1HDAC2HDAC3TRIM24 | |
| SCHEMBL27979565 | 0.83 | HDAC1 (0.38) | QDPRHDAC1HDAC2HDAC3NAMPT | |
| SCHEMBL27724744 | 0.83 | HDAC1 (0.38) | QDPRHDAC1HDAC2HDAC3NAMPT | |
| SCHEMBL27945504 | 0.83 | HDAC1 (0.38) | QDPRHDAC1HDAC2HDAC3NAMPT | |
| SCHEMBL2112595 | 0.82 | GPR119 (0.54) | GPR119THRBNAMPTPDE4B | |
| SCHEMBL27949194 | 0.82 | HDAC1 (0.38) | QDPRHDAC1HDAC2HDAC3NAMPT | |
| SCHEMBL27933803 | 0.82 | QDPR (0.48) | QDPRPDE4B | |
| SCHEMBL27933802 | 0.81 | HDAC1 (0.37) | QDPRHDAC1HDAC2HDAC3NAMPT | |
| SCHEMBL27318172 | 0.79 | SLC18A3 (0.44) | QDPRHDAC1HDAC2HDAC3GPR119 | |
| SCHEMBL27945028 | 0.79 | CCR5 (0.41) | QDPRHDAC1HDAC2HDAC3PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101578265-B | Sulfonamide derivatives as chymase inhibitors | HOFFMANN LA ROCHE | 2013-05-08 | — | — | CN | disclosed |
| CN-101578265-A | Sulfonamide derivatives as chymase inhibitors | HOFFMANN LA ROCHE (CH) | 2009-11-11 | — | — | CN | disclosed |