Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2439786 | 0.85 | ADRB2 (0.58) | SYKADRB2ADRB1CYP2D6NFKB1 | |
| SCHEMBL8242919 | 0.84 | DRD2 (0.48) | SYKPOLBIDO1MALT1KDM4A | |
| SCHEMBL256636 | 0.83 | SYK (0.44) | SYKADRB2ADRB1CYP2D6NFKB1 | |
| SCHEMBL23011458 | 0.83 | SYK (0.44) | SYKADRB2ADRB1CYP2D6NFKB1 | |
| SCHEMBL12679224 | 0.82 | CTSS (0.46) | SYKADRB2ADRB1MALT1MEN1 | |
| SCHEMBL29848484 | 0.81 | PTGFR (0.46) | SYKADRB2ADRB1CYP2D6NFKB1 | |
| SCHEMBL21609310 | 0.81 | PTGFR (0.46) | SYKADRB2ADRB1CYP2D6NFKB1 | |
| SCHEMBL1624872 | 0.80 | CTSK (0.51) | SYKATMIDO1MALT1MEN1 | |
| SCHEMBL2727399 | 0.80 | CTSK (0.51) | SYKATMIDO1MALT1MEN1 | |
| SCHEMBL3640547 | 0.80 | CTSK (0.51) | SYKATMIDO1MALT1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101646427-B | Inhibitors of akt activity | SMITHKLINE BEECHAM CORP US | 2013-06-12 | — | — | CN | disclosed |
| CN-101646427-A | Inhibitors of akt activity | SMITHKLINE BEECHAM CORP US | 2010-02-10 | — | — | CN | disclosed |