Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | LSS | P48449 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776698 | 0.93 | MTNR1A (0.35) | MTNR1AFFAR4ESR1ESR2AR | |
| SCHEMBL2778779 | 0.81 | PNMT (0.46) | ARADRA2AADRA2BADRA2C | |
| SCHEMBL2778013 | 0.79 | PNMT (0.39) | MTNR1AFFAR4ESR1ESR2AR | |
| SCHEMBL2778693 | 0.77 | ACHE (0.41) | MTNR1AFFAR4 | |
| SCHEMBL15263464 | 0.74 | CA9 (0.41) | MTNR1AFFAR4AR | |
| SCHEMBL2777417 | 0.72 | ACHE (0.41) | MTNR1AFFAR4LSS | |
| SCHEMBL2781327 | 0.70 | NR1H2 (0.36) | MTNR1AFFAR4AR | |
| SCHEMBL2780371 | 0.70 | MTNR1A (0.38) | MTNR1AFFAR4AR | |
| SCHEMBL7140193 | 0.69 | MTNR1A (0.34) | MTNR1AESR1ESR2 | |
| SCHEMBL9394761 | 0.67 | AR (0.40) | MTNR1AESR1ESR2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139886-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | Neuraxon Inc. (CA) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116308-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2008-10-02 | — | — | WO | disclosed |