Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | LDLR | P01130 | 1/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27522705 | 0.78 | ADRA2C (0.54) | HTR1AADRA2CHTR1DHTR1BHTR2A | |
| SCHEMBL12359403 | 0.77 | MAPT (0.54) | NPC1RAB9ALMNAHTR1AADRA2C | |
| SCHEMBL14922328 | 0.77 | ALDH1A1 (0.52) | NPC1RAB9AADRA2CALDH1A1KDM4E | |
| SCHEMBL27941708 | 0.73 | RAPGEF4 (0.41) | LMNAALDH1A1 | |
| SCHEMBL12659839 | 0.73 | BCL2A1 (0.49) | NPC1RAB9ALMNAHTR1AADRA2C | |
| SCHEMBL31527732 | 0.71 | RAPGEF4 (0.39) | LMNAALDH1A1 | |
| SCHEMBL8263604 | 0.69 | FFAR4 (0.45) | NPC1RAB9ALMNAADRA2CALDH1A1 | |
| SCHEMBL5172916 | 0.69 | MAPT (0.46) | NPC1RAB9ALMNAAPPALDH1A1 | |
| SCHEMBL18278152 | 0.69 | ADRA2C (0.59) | NPC1RAB9ALMNAHTR1AADRA2C | |
| SCHEMBL18294443 | 0.69 | ADRA2C (0.42) | NPC1RAB9ALMNAAPPHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101668749-A | Novel pyrimidine derivatives 698 | ASTRAZENECA AB | 2010-03-10 | — | — | CN | disclosed |