Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | AGXT | P21549 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.45 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.45 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.45 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2378486 | 0.80 | ADRA2C (0.61) | ADRA2CHTR2AHTR1AHTR2CHTR7 | |
| SCHEMBL14922328 | 0.80 | ALDH1A1 (0.52) | ADRA2CKDM1A | |
| SCHEMBL13996557 | 0.79 | ADRA2C (0.56) | ADRA2CHTR2AHTR1AHTR2CHTR7 | |
| SCHEMBL5543193 | 0.78 | ADRA2C (0.54) | ADRA2CHTR2AHTR1AHTR2CHTR7 | |
| SCHEMBL5543197 | 0.78 | ADRA2C (0.54) | ADRA2CHTR2AHTR1AHTR2CHTR7 | |
| SCHEMBL27773145 | 0.78 | NPC1 (0.40) | ADRA2CHTR2AHTR1AHTR1DHTR1B | |
| SCHEMBL28000258 | 0.77 | HTR2A (0.64) | ADRA2CHTR2AHTR1AHTR2CHTR7 | |
| SCHEMBL30577378 | 0.77 | HTR1D (0.60) | HTR2AHTR1AHTR7HTR1DHTR1B | |
| SCHEMBL18230177 | 0.77 | HTR7 (0.63) | ADRA2CHTR2AHTR1AHTR2CHTR7 | |
| SCHEMBL25156906 | 0.76 | ADRA2C (0.56) | ADRA2CHTR2AHTR1AHTR2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1246116-A | Sulfonamide derivatives, process for their preparation and their use as medicaments | SMITHKLINE BEECHAM PLC (GB) | 2000-03-01 | — | — | CN | claimed |