Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.86 |
| ▸ | MAPT | P10636 | 1/20 | 0.86 |
| ▸ | PDE4A | P27815 | 1/20 | 0.86 |
| ▸ | KDR | P35968 | 1/20 | 0.86 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL27262335 | 1.00 | — | — | |
| Piperazine SCHEMBL27773496 | 0.94 | HIF1A (0.75) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27737062 | 0.94 | — | — | |
| Piperazine SCHEMBL27457267 | 0.94 | — | — | |
| Piperazine SCHEMBL27402227 | 0.94 | — | — | |
| SCHEMBL22003 | 0.93 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL734764 | 0.93 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL238 | 0.93 | — | — | |
| SCHEMBL3999265 | 0.93 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL577429 | 0.93 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105473559-B | Carbonyl β-carbon activation for chemical conversion | 南洋理工大学 | 2019-05-10 | — | — | CN | disclosed |
| CN-105473559-A | Activation of carbonyl [beta]-carbons for chemical transformations | UNIV NANYANG TECH | 2016-04-06 | — | — | CN | disclosed |
| CN-101463285-A | Preparation of soap salt-phosphazene composite lubricating film | LANZHOU INST CHEM PHYSICS CAS (CN) | 2009-06-24 | — | — | CN | disclosed |