Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14368758 | 1.00 | HPGD (0.43) | HPGDMEN1KMT2AMAPTPKM | |
| SCHEMBL14368748 | 0.78 | TP53 (0.48) | HPGDKMT2ASIGMAR1NPC1RAB9A | |
| SCHEMBL27778439 | 0.78 | TP53 (0.48) | HPGDKMT2ASIGMAR1NPC1RAB9A | |
| SCHEMBL14368694 | 0.78 | MCHR1 (0.52) | HPGDMAPTSIGMAR1TP53 | |
| SCHEMBL28783269 | 0.78 | MCHR1 (0.52) | HPGDMAPTSIGMAR1TP53 | |
| SCHEMBL14368761 | 0.77 | C3AR1 (0.50) | MAPTSIGMAR1ALDH1A1 | |
| SCHEMBL27757311 | 0.77 | C3AR1 (0.50) | MAPTSIGMAR1ALDH1A1 | |
| SCHEMBL14368751 | 0.77 | NPC1 (0.52) | HPGDSIGMAR1NPC1RAB9AALDH1A1 | |
| SCHEMBL27757307 | 0.77 | NPC1 (0.52) | HPGDSIGMAR1NPC1RAB9AALDH1A1 | |
| SCHEMBL14368701 | 0.76 | POLB (0.53) | MEN1KMT2ASIGMAR1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101484442-A | Compounds that are agonists of muscarinic receptors and tha may be effective in treating pain, alzheimer's disease and/or schizophrenia | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | claimed |
| CN-101484442-A | Compounds that are agonists of muscarinic receptors and tha may be effective in treating pain, alzheimer's disease and/or schizophrenia | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | disclosed |