Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | S100A4 | P26447 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14368748 | 1.00 | TP53 (0.48) | TP53TSHRLMNAPOLBHPGD | |
| SCHEMBL14368701 | 0.84 | POLB (0.53) | POLBKMT2AALDH1A1SIGMAR1 | |
| SCHEMBL14368694 | 0.82 | MCHR1 (0.52) | TP53POLBHPGDSIGMAR1 | |
| SCHEMBL28783269 | 0.82 | MCHR1 (0.52) | TP53POLBHPGDSIGMAR1 | |
| SCHEMBL27757307 | 0.81 | NPC1 (0.52) | HPGDALDH1A1NPC1RAB9ASIGMAR1 | |
| SCHEMBL14368751 | 0.81 | NPC1 (0.52) | HPGDALDH1A1NPC1RAB9ASIGMAR1 | |
| SCHEMBL28944630 | 0.80 | TAS1R3 (0.49) | LMNAHPGDKMT2AALDH1A1RAB9A | |
| SCHEMBL14368778 | 0.80 | TAS1R3 (0.49) | LMNAHPGDKMT2AALDH1A1RAB9A | |
| SCHEMBL14368758 | 0.78 | HPGD (0.43) | TP53TSHRHPGDKMT2AALDH1A1 | |
| SCHEMBL27778261 | 0.78 | HPGD (0.43) | TP53TSHRHPGDKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101484442-A | Compounds that are agonists of muscarinic receptors and tha may be effective in treating pain, alzheimer's disease and/or schizophrenia | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | claimed |
| CN-101484442-A | Compounds that are agonists of muscarinic receptors and tha may be effective in treating pain, alzheimer's disease and/or schizophrenia | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | disclosed |