Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 4/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14368751 | 1.00 | NPC1 (0.52) | NPC1EPHX2CCR3THRBHPGD | |
| SCHEMBL14368694 | 0.87 | MCHR1 (0.52) | CCR3HPGDSIGMAR1 | |
| SCHEMBL28783269 | 0.87 | MCHR1 (0.52) | CCR3HPGDSIGMAR1 | |
| SCHEMBL28779126 | 0.85 | CCR3 (0.56) | CCR3SIGMAR1ALDH1A1ACKR3 | |
| SCHEMBL14368761 | 0.82 | C3AR1 (0.50) | SIGMAR1ALDH1A1 | |
| SCHEMBL27757311 | 0.82 | C3AR1 (0.50) | SIGMAR1ALDH1A1 | |
| SCHEMBL14368748 | 0.81 | TP53 (0.48) | NPC1HPGDSIGMAR1ALDH1A1RAB9A | |
| SCHEMBL27778439 | 0.81 | TP53 (0.48) | NPC1HPGDSIGMAR1ALDH1A1RAB9A | |
| SCHEMBL14368730 | 0.79 | POLB (0.58) | CCR3HPGDSIGMAR1ALDH1A1ACKR3 | |
| SCHEMBL28783273 | 0.79 | POLB (0.58) | CCR3HPGDSIGMAR1ALDH1A1ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101484442-A | Compounds that are agonists of muscarinic receptors and tha may be effective in treating pain, alzheimer's disease and/or schizophrenia | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | claimed |
| CN-101484442-A | Compounds that are agonists of muscarinic receptors and tha may be effective in treating pain, alzheimer's disease and/or schizophrenia | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | disclosed |