Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 5/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14368809 | 1.00 | F10 (0.49) | F10ACKR3NPC1CCR3TAS1R3 | |
| SCHEMBL14368754 | 0.86 | NPC1 (0.48) | NPC1CCR3TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL14392662 | 0.85 | CCR3 (0.44) | CCR3 | |
| SCHEMBL27757451 | 0.84 | CCR3 (0.48) | ACKR3NPC1CCR3 | |
| SCHEMBL14368703 | 0.82 | CHRNA7 (0.51) | F10NPC1MCHR1MAPT | |
| SCHEMBL14392352 | 0.82 | CHRNA7 (0.51) | F10NPC1MCHR1MAPT | |
| SCHEMBL27757300 | 0.82 | CHRNA7 (0.51) | F10NPC1MCHR1MAPT | |
| SCHEMBL28944630 | 0.80 | TAS1R3 (0.49) | F10ACKR3TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL14368778 | 0.80 | TAS1R3 (0.49) | F10ACKR3TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL14368686 | 0.77 | HRH3 (0.57) | NPC1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101484442-A | Compounds that are agonists of muscarinic receptors and tha may be effective in treating pain, alzheimer's disease and/or schizophrenia | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | claimed |
| CN-101484442-A | Compounds that are agonists of muscarinic receptors and tha may be effective in treating pain, alzheimer's disease and/or schizophrenia | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | disclosed |