Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KLK7 | P49862 | 1/20 | 0.53 |
| ▸ | PARP14 | Q460N5 | 14/20 | 0.50 |
| ▸ | KIF11 | P52732 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GPR3 | P46089 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9490444 | 0.79 | KIF11 (0.59) | JAK2TP53MAPTHTTKLK7 | |
| SCHEMBL27761900 | 0.76 | TDO2 (0.54) | MAPTPARP14ALDH1A1HSD17B10 | |
| SCHEMBL1146610 | 0.76 | KIF11 (0.55) | JAK2TP53MAPTHTTKLK7 | |
| SCHEMBL20887128 | 0.76 | KIF11 (0.60) | JAK2TP53MAPTHTTKLK7 | |
| SCHEMBL29206609 | 0.76 | JAK2 (0.57) | JAK2TP53MAPTHTTKLK7 | |
| SCHEMBL27648564 | 0.75 | JAK2 (0.53) | JAK2TP53MAPTHTTKLK7 | |
| SCHEMBL9501877 | 0.75 | KIF11 (0.50) | JAK2TP53MAPTHTTKLK7 | |
| SCHEMBL2446017 | 0.74 | KIF11 (0.53) | JAK2TP53MAPTHTTKLK7 | |
| SCHEMBL3077145 | 0.74 | JAK2 (0.68) | JAK2TP53MAPTHTTKLK7 | |
| SCHEMBL30346387 | 0.73 | MAPT (0.59) | JAK2TP53MAPTHTTKLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104245675-B | Cyclic amides as MetAP-2 inhibitors | 默克专利股份公司 | 2017-10-13 | — | — | CN | disclosed |
| CN-103930416-B | BENZONITRILE DERIVATIVES AS KINASE INHIBITORS | 默克专利股份公司 | 2017-03-29 | — | — | CN | disclosed |
| CN-103153951-B | Pyrrolidones as MetAP-2 inhibitors | MERCK PATENT GMBH (DE) | 2016-05-25 | — | — | CN | disclosed |
| CN-101674820-B | Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy | PHARMACYCLICS INC | 2013-09-25 | — | — | CN | disclosed |
| CN-103153951-A | Pyrrolidones as MetAP-2 inhibitors | MERCK PATENT GMBH | 2013-06-12 | — | — | CN | disclosed |
| CN-101674820-A | The method of using histone deacetylase inhibitors and monitoring biomarkers in therapeutic alliance | PHARMACYCLICS INC | 2010-03-17 | — | — | CN | disclosed |