Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KLK7 | P49862 | 1/20 | 0.53 |
| ▸ | PARP14 | Q460N5 | 10/20 | 0.50 |
| ▸ | KIF11 | P52732 | 4/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GPR3 | P46089 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28188584 | 0.90 | POLB (0.55) | JAK2TP53MAPTHTTKLK7 | |
| SCHEMBL28166021 | 0.82 | JAK2 (0.38) | JAK2TP53MAPTHTTKLK7 | |
| SCHEMBL9501877 | 0.82 | KIF11 (0.50) | JAK2TP53MAPTHTTKLK7 | |
| SCHEMBL28861294 | 0.82 | PARP14 (0.50) | JAK2TP53MAPTHTTKLK7 | |
| SCHEMBL28905717 | 0.81 | PARP1 (0.54) | ALDH1A1GPR3HSD17B10PABPC1 | |
| SCHEMBL27973848 | 0.81 | IMPDH2 (0.49) | MAPTHTTKIF11ALDH1A1GPR3 | |
| SCHEMBL9490444 | 0.79 | KIF11 (0.59) | JAK2TP53MAPTHTTKLK7 | |
| SCHEMBL28166035 | 0.78 | CDK4 (0.43) | MAPTPABPC1 | |
| SCHEMBL28164562 | 0.76 | AHR (0.53) | TP53MAPTPARP14PIM1PIM3 | |
| SCHEMBL1146610 | 0.76 | KIF11 (0.55) | JAK2TP53MAPTHTTKLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105473573-B | Carbazole carboxamide compounds useful as kinase inhibitor | 百时美施贵宝公司 | 2018-03-16 | — | — | CN | claimed |
| CN-107108555-A | Three ring atropisomer compounds | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | claimed |
| CN-107074804-A | Carbazole derivates | 百时美施贵宝公司 | 2017-08-18 | — | — | CN | claimed |
| CN-110312713-A | Process for preparing tetrahydrocarbazole carboxamide compounds | 百时美施贵宝公司 | 2019-10-08 | — | — | CN | disclosed |
| CN-110194772-A | For inhibiting (miscellaneous) the fragrant cyclics of the alkynyl of protein kinase activity | 深圳市塔吉瑞生物医药有限公司 | 2019-09-03 | — | — | CN | disclosed |
| CN-109890846-A | anti-CD 27 antibodies | 默沙东公司 | 2019-06-14 | — | — | CN | disclosed |
| CN-109851620-A | For inhibiting the condensed-bicyclic class compound of tyrosine kinase activity | 深圳市塔吉瑞生物医药有限公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-109803686-A | Composition comprising source metal, dithiocar-bamate and cyclodextrin | 德国癌症研究公共权益基金会 | 2019-05-24 | — | — | CN | disclosed |
| CN-108368119-B | Fused Bicyclic Compounds for Inhibiting Tyrosine Kinase Activity | 深圳市塔吉瑞生物医药有限公司 | 2019-04-23 | — | — | CN | disclosed |
| CN-105307656-B | Quinoline inhibitors of macrophage stimulating 1 receptor MST1R | 利德发现中心有限责任公司 | 2019-02-19 | — | — | CN | disclosed |
| CN-108473476-A | Alkynyl heterocyclic compounds for inhibiting protein kinase activity | 深圳市塔吉瑞生物医药有限公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-102480966-A | Fused heterocyclic compounds and uses thereof | NOVARTIS AG | 2012-05-30 | — | — | CN | disclosed |
| CN-102017525-A | Inhibitors of checkpoint kinases | MERCK & CO INC | 2011-04-13 | — | — | CN | disclosed |
| CN-101932572-A | Pharmaceutically acceptable salts of 2- {4- [ (3S) -piperidin-3-yl ] phenyl } -2H-indazole-7-carboxamide | MERCK & CO INC | 2010-12-29 | — | — | CN | disclosed |
| CN-101855221-A | Pyridazinone derivatives as PARP inhibitors | ANGELETTI P IST RICHERCHE BIO | 2010-10-06 | — | — | CN | disclosed |
| CN-101600706-A | Inhibitors of AKT activity | MERCK & CO INC (US) | 2009-12-09 | — | — | CN | disclosed |
| CN-101578279-A | Amide substituted indazoles as poly (ADP ribose) polymerase (PARP) inhibitors | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-11-11 | — | — | CN | disclosed |
| CN-100403900-C | Mitotic kinesin inhibitors | MERCK & CO INC (US) | 2008-07-23 | — | — | CN | disclosed |
| CN-101203495-A | Benzocycloheptapyridine compounds as inhibitors of receptor tyrosine kinase MET | MERCK & CO INC (US) | 2008-06-18 | — | — | CN | disclosed |
| CN-1805686-A | Mitotic kinesin inhibitors | MERCK & CO INC (US) | 2006-07-19 | — | — | CN | disclosed |