Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27799817 | 0.88 | MAPT (0.39) | MEP1BMAPTCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL27778788 | 0.84 | CYP1A2 (0.46) | MAPTCYP1A2CYP2C19CYP3A4MEN1 | |
| SCHEMBL14208999 | 0.82 | CYP1A2 (0.39) | MAPTCYP1A2CYP2C19CYP3A4MEN1 | |
| SCHEMBL27581775 | 0.81 | MEP1B (0.43) | MEP1BCES2CES1ALDH1A1HIF1A | |
| SCHEMBL5743863 | 0.80 | HPGDS (0.46) | MEP1BMAPTCES2CES1SMN1; SMN2 | |
| SCHEMBL606872 | 0.79 | TDP1 (0.49) | MEP1BMAPTCYP1A2CES2CES1 | |
| SCHEMBL201535 | 0.77 | CES2 (0.44) | MEP1BMAPTCES2CES1LMNA | |
| SCHEMBL12828895 | 0.77 | MEP1B (0.44) | MEP1BMAPTKMT2ACES2CES1 | |
| SCHEMBL27878806 | 0.76 | MEP1B (0.43) | MEP1BMAPTCYP1A2MEN1KMT2A | |
| SCHEMBL1555844 | 0.76 | CPS1 (0.52) | MAPTMEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679287-B | Nicotinic acetylcholine receptor modulators | SIENA BIOTECH SPA | 2013-03-27 | — | — | CN | disclosed |
| CN-101679287-A | nicotinic acetylcholine receptor modulators | SIENA BIOTECH SPA | 2010-03-24 | — | — | CN | disclosed |