Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27780826 | 0.88 | HTR2A (0.37) | HTR2AHTR2CCYP11B2CYP11B1MAPT | |
| SCHEMBL28799146 | 0.82 | HTR2A (0.36) | HTR2AHTR2CCYP11B2CYP11B1KDM4E | |
| SCHEMBL30095703 | 0.73 | KDM4E (0.42) | HTR2AHTR2CCYP11B2CYP11B1KDM4E | |
| SCHEMBL28799118 | 0.71 | HTR2A (0.36) | HTR2AHTR2CALDH1A1MAPTMAT2A | |
| SCHEMBL27780893 | 0.71 | PLK1 (0.43) | HTR2AHTR2CCYP11B2KDM4EALDH1A1 | |
| SCHEMBL28779598 | 0.69 | HTR2C (0.36) | HTR2AHTR2CKDM4EALDH1A1HPGD | |
| SCHEMBL29094005 | 0.69 | HTR2A (0.35) | HTR2AHTR2CCYP11B2CYP11B1KDM4E | |
| SCHEMBL28799125 | 0.67 | BTK (0.34) | KDM4EALDH1A1 | |
| SCHEMBL28799104 | 0.66 | SLC6A2 (0.32) | ALDH1A1 | |
| SCHEMBL28799114 | 0.66 | KMO (0.35) | MAPTMEN1KMT2AMAT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101516889-B | Derivatives and analogs of n-ethylquinolones and n-ethylazaquinolones | GLAXO GROUP LTD | 2013-07-31 | — | — | CN | disclosed |
| CN-101516889-A | Derivatives and analogs of n-ethylquinolones and n-ethylazaquinolones | GLAXO GROUP LTD (GB) | 2009-08-26 | — | — | CN | disclosed |