Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7158572 | 0.83 | CTSK (0.41) | KDM4ENPC1RAB9ACTSSCTSK | |
| SCHEMBL27780853 | 0.77 | NPC1 (0.44) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10627226 | 0.77 | PTK2 (0.50) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL11498343 | 0.75 | PTK2 (0.56) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL4144089 | 0.74 | KMT2A (0.47) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL7474279 | 0.74 | KMT2A (0.51) | KDM4EKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL219602 | 0.74 | ADRA1A (0.55) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL1703720 | 0.72 | KMT2A (0.66) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL9135107 | 0.72 | GSK3B (0.41) | KDM4ENPC1RAB9AKMT2AGAA | |
| SCHEMBL162737 | 0.72 | ALDH1A1 (0.37) | KDM4ENPC1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541783-B | pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2014-10-01 | — | — | CN | disclosed |
| CN-101541783-A | Pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS (US) | 2009-09-23 | — | — | CN | disclosed |