Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 12/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27760113 | 0.86 | PNMT (0.44) | PNMTADRA2AADRA2BADRA2CCMA1 | |
| SCHEMBL27797441 | 0.83 | HTR2A (0.50) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL27650137 | 0.79 | CHRNB2 (0.35) | — | |
| SCHEMBL27670223 | 0.79 | DRD2 (0.43) | HTR2C | |
| SCHEMBL27923870 | 0.79 | PNMT (0.41) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL27543455 | 0.79 | CHRNB2 (0.35) | — | |
| SCHEMBL27650127 | 0.79 | PNMT (0.41) | PNMTADRA2AADRA2BADRA2CCMA1 | |
| SCHEMBL27884574 | 0.76 | DRD2 (0.33) | — | |
| SCHEMBL30435099 | 0.74 | CYP2D6 (0.38) | ADRA2AADRA2BADRA2C | |
| SCHEMBL3087062 | 0.74 | CYP2D6 (0.38) | ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113429333-B | Synthesis method of gatifloxacin intermediate | 江苏法安德医药科技有限公司 | 2022-03-04 | — | — | CN | disclosed |
| CN-110938028-B | Preparation method of (1R) -5-bromo-2, 3-dihydro-1-methyl-1H-isoindole | 南京杰运医药科技有限公司 | 2022-03-04 | — | — | CN | disclosed |
| CN-113429333-A | Synthesis method of gatifloxacin intermediate | 江苏法安德医药科技有限公司 | 2021-09-24 | — | — | CN | disclosed |
| CN-110938028-A | Preparation method of (1R) -5-bromo-2, 3-dihydro-1-methyl-1H-isoindole | 南京杰运医药科技有限公司 | 2020-03-31 | — | — | CN | disclosed |
| CN-102858767-B | As the aminopyrimidine of SYK inhibitor | MERCK SHARP & DOHME CORP. (US) | 2015-08-19 | — | — | CN | disclosed |
| CN-102858767-A | Aminopyrimidines as SYK inhibitors | MERCK SHARP & DOHME | 2013-01-02 | — | — | CN | disclosed |
| CN-101558067-A | 2-methylmorpholine pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as MTOR inhibitors | KUDOS PHARM LTD (GB) | 2009-10-14 | — | — | CN | disclosed |